Roche Switzerland bridges the gap between pharmaceuticals and diagnostics. Important research and development functions are located here. For our long-term client, F. Hoffmann-La Roche AG in Basel, we are looking for a
Research Associate for in vivo Nonmalignant Hematology Research
Background:
We are seeking a Research Associate to support the preclinical evaluation of novel therapies for nonmalignant hematologic disorders, including bleeding and thrombotic diseases and anemia. Working within a multidisciplinary team, you will assess efficacy, safety, and translational relevance using complementary in vivo and ex vivo approaches with preclinical animal models and human blood and plasma samples. While this role is sitting in the Discovery unit, they work very closely together with clinical teams. Hence, the role requires end-to-end experimental ownership, including hands-on animal studies, sample collection and processing, execution of functional assays, data analysis, and characterization of drug candidates in hemostasis and thrombosis.
Tasks & Responsibilities:
- Design, execute and analyze diverse in vivo and in vitro experiments in the field of coagulation
- Demonstrated hands-on experience with rodent work, including intravenous injections and blood collection
- Characterize efficacy and safety of novel pharmaceutical assets using molecular and biochemical assays (e.g., ELISA, thrombin generation assay, chromogenic assays) in murine and human samples
- Prepare, handle, and test patient-derived material (blood and plasma) in in vitro and ex vivo settings
- Perform data analysis and present results within the team
- Maintain thorough documentation and contribute to general lab organization, safety, and inventory management
Must Haves:
- MSc or BSc in Life Sciences (e.g., molecular biology, pharmacology, immunology,coagulation) with at least 2-3 years hands-on animal study experience (No PhD accepted)
- Or, completed an apprenticeship as Research Associate (“Lehrabschluss”) with at least 4-5 years of academic or industry experience
- Active LTK1 certification, FELASA certification, or equivalent, ideally with current mandatory continuing-education requirements already fulfilled
- Strong hands-on in vivo skills including compound administration, monitoring and organ sampling
- Strong hands-on experience of in vitro assays, including but not limited to DNA/RNA isolation, ELISA, qPCR, biochemical assays and protein-based assays
- Strong experience and independence in experimental design and data analysis
- Ability to independently execute and manage in vivo and in vitro studies from start to finish
- Fluency in English
Nice to Have:
- Hands-on experience with thrombin generation and chromogenic substrate assays
- Experience performing surgical procedures in rodents, such as in vivo thrombosis assays and in vivo bleeding models.
- Knowledge of coagulation, hemostasis, bleeding, or thrombosis biology
- Prior pharmaceutical or biotechnology industry experience
What you will be offered:
- An opportunity to work in one of the world's most important pharmaceutical companies
- Modern campus with plenty of green spaces and meeting areas
- Central location in Basel
- Varied job profile
- Further training opportunities through temptraining
- Working in a dynamic and motivated team
If you are interested please send your application documents addressed to Ms Diana Afonso.
Basel-Stadt Aargau Solothurn Pharma Research Associate in vivo Scientific Associate Labor Laboratory